Next-Generation Primary Allogeneic CAR NK cells
oNKCAR138 & oNKCAR21: CARs inserted into specific loci within primary human NK cells to regulate expression and increase NK cell activation and function.
Blocking antibodies and decoy receptors that prevent NK cell suppression in the tumor microenvironment, oNK05 at target validation stage.
Functional genomic screens to define molecular ‘handles’ to increase NK cell targeting of tumors via Bi/Tri-specific killer engagers. oNK03 & oNK04 progressed to Target Validation
Targets that increase NK cell trafficking and retention within tumors.