Introduction
Natural killer (NK) cells are a major focus of novel anti-cancer therapies. Target discovery in NK cells has been so far hampered by their resistance to genetic manipulation. Here we present an integrated CRISPR-based framework for large-scale screening and drug target discovery in human and murine NK cells.
Key takeaways:
- Systematic functional screening in human NK cells reveals novel regulators of IL-15 axis, NK cell cytotoxicity and IFNγ release
- Target deletion boosts NK cell proliferation and chronic killing capacity as well as NK cell anti-metastatic function in vivo
For the full poster PDF click here or on the image below.
![](https://www.onko-innate.com/wp-content/uploads/2023/12/Systematic-target-discovery-in-NK-cells_Iva-Nikolic.png)