Introduction
Natural killer (NK) cells are a major focus of novel anti-cancer therapies. Target discovery in NK cells has been so far hampered by their resistance to genetic manipulation. Here we present an integrated CRISPR-based framework for large-scale screening and drug target discovery in human and murine NK cells.
Key takeaways:
- Systematic functional screening in human NK cells reveals novel regulators of IL-15 axis, NK cell cytotoxicity and IFNγ release
- Target deletion boosts NK cell proliferation and chronic killing capacity as well as NK cell anti-metastatic function in vivo
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