Systematic target discovery in human NK cells using functional genomics

Schematic outline of oNKo-Innate NK cell screening platform


Natural killer (NK) cells are a major focus of novel anti-cancer therapies. Target discovery in NK cells has been so far hampered by their resistance to genetic manipulation. Here we present an integrated CRISPR-based framework for large-scale screening and drug target discovery in human and murine NK cells.

Key takeaways:

  • Systematic functional screening in human NK cells reveals novel regulators of IL-15 axis, NK cell cytotoxicity and IFNγ release
  • Target deletion boosts NK cell proliferation and chronic killing capacity as well as NK cell anti-metastatic function in vivo

For the full poster PDF click here or on the image below.

Iva Nikolic

Chief Technology Officer

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